Blimey, the first time I stumbled upon that locked door in the Wormways, I thought I'd found a secret stash of rosaries. Instead, I found a bloke named Alchemist Zylotol who's absolutely obsessed with Lifeblood—or as he calls it, Plasmium. And let me tell you, this quest is a proper mix of curiosity and creepy-crawly chaos. If you're like me and you enjoy a bit of exploration with a side of murderous flesh-eating worms, then this is right up your alley. If not, don't worry—I'll show you how to grab the three Plasmium samples and get out of there sharpish.

Where to Find the Quest

First things first: you need a Simple Key. I grabbed mine from the vendor in Bone Bottom for 500 Rosary Beads—cost me an arm and a leg, but it's the easiest one to get early on. You'll also need the Cling Grip from Shellwood, otherwise you won't be able to traverse the Wormways. Trust me, I tried without it and ended up face-planting into a wall more times than I care to admit.

Head to the entrance of the Wormways, due west of Mosshome. You'll have to jump across a gap where two large cages are hanging—keep your eyes peeled for that. Keep heading west until you find a large door. Use your Simple Key and step inside.

Wend your way upwards through the area. At the very top, through a vertical shaft, you'll bump into Alchemist Zylotol. He'll give you the Wish and a tool to help with the job. Nice bloke, really—just a bit too keen on worm juice.

Finding the Plasmium Buds

Before you head down, equip the tool Zylotol gave you using the bench on the left. It counts as a red tool in your slots and works like a Sting Shard—just activate it when you're near a bud.

Here's a quick summary of the three buds:

Bud 1

The first bud is in the chamber below Zylotol, marked in the image above. Keep an eye out for those cheeky little worms that burst out of the ground and try to bite you. If you have the Crest of the Wanderer, you can quick-slash and keep them at bay before they reach you. Piece of cake, really.

Bud 2

The next bud is way down, right at the base of the Wormways where it starts to blend in with the Moss Grotto. Head down and to the east—when the area starts looking green, you'll know you're in the right place. Head down a short corridor to find the bud. While you're there, do yourself a favor and open the shortcut right below the bud that leads back into the Moss Grotto. It'll save you a headache later.

Bud 3

The final bud is in the large chamber to the southwest. You'll find it all the way to the left, just after the entrance to the westmost chamber. Suck up the final bud and then hightail it back to Alchemist Zylotol.

Quest Rewards

Once you return, Zylotol will congratulate you and hand over a Plasmium Phial. This little beauty is a red tool that gives you an extra temporary mask of health. It has three uses per charge, and it recharges when you sit on a bench. In total, you get 20 uses. Once you've run out of phial charges, you can pop back to Zylotol for a refill in exchange for rosary beads. Not a bad deal, eh?

So there you have it—a quick and dirty guide to the Plasmium Buds quest. It's a bit of a slog through worm-infested tunnels, but the reward is well worth it. And hey, as of 2026, this quest is still one of the more memorable side adventures in Silksong. Cheers, and happy hunting! 🐛🔑🧪

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